Book Club System: How It Works & How You Win – BioInformatics Gate

Course Content

Before You Start: Book Club Orientation

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Book Club System: How It Works & How You Win

Bioinformation Discovery: Data to Knowledge in Biology | Book Club |

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Bioinformation Discovery: Data to Knowledge in Biology | Book Club |

chapter 1.Bioinformatics for Bioinformation

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1. 1 Bioinformatics

1. 2 Bioinformatics Related Terms

1. 5 .1 UNIX Commands for Bioinformation Discovery

1. 6 Bioinformatics Warehousing in Drug Discovery

1. 8 Bioinformation Graphics in Biology

1. 9 Bioinformatics Variables

1. 10 Cell Constituents

1. 11 Codon and Codon Usage Table

1. 12 Bioinformation Discovery

1 .14 Bioinformatics Challenges

1. 15 Biological Data

1 .16 Data Explosion

1. 17 Sequence Data

1 .18 Structure Data

1. 21 SCOP Datas

1. 22 CATH Dataset

1. 24 Pathway Data

1. 26 Discovery Environment

1. 27 Sequence, Structure Alignment, and Evolutionary Inferences

1. 28 Molecular Modeling

1. 29 Molecular Docking

1. 30 Phylogenetic Analysis

1 .31 Exercises

Chapter 2 Creating Datasets for Bioinformation

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2 5 PDB Chain Identifier peptide binding groove

2 8 Structural Parameters for MHC Peptide Dataset Analysis

2 11 Intronless Genes Dataset

2 13 Intron Containing Genes Dataset

2 15 Cholera Toxin Dataset

Chapter 3

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3 24 ROSETTA Design

3 27 T EPITOPE DESIGNER

Chapter 4 Protein Protein Interaction

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4 1 Protein Subunit Interaction

4 3 Parameters in Subunit Interaction

Conclusion 105 4 5 Exercise

Chapter 5 Homodimer Folding and Binding

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5 1 Importance of Homodimers

5 2 Homodimer Folding

5 3 Homodimer Structures in Folding

5 4 Size, Interface Area, and Structure

5 5 Interface to Total Residues

5 6 Large, Medium, Small Interfaces

5 7 Folding and Binding Mechanism

Chapter 6 Fusion Proteins

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6 1 Gene Fusion

6 2 Operons in Prokaryotes

6 4 Alternative Splicing in Fusion Genes

6 6 Mechanism of Gene Fusion

6 7 Hypothesis of Gene Fusion

6 8 Structural Importance of Fusion Proteins

6 8 4 Interface Area in IGPS

Chapter 7 MHC Informatics to Peptide Vaccine Design

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7 1 MHC Biology and Diversity

7 2 Promise of MHC in Medicine

7 3 MHC Structure and Function

7 3 2 Class II MHC Structure and Function

7 4 MHC Peptide Motifs

7 5 MHC Peptide Binding

7 7 MHC Peptide Complex in T Cell Mediated Immune Response

7 8 MHC Peptide Binding Predictions

7 8 2 Molecular Modeling Methods

7 8 3 Molecular Modeling Limitations

7 9 Application of MHC Peptide Prediction

7 10 T EPITOPE Designer

7 11 HLA Supertypes

7 11 4 Predictive Grouping of HLA Supertypes

Chapter 8 Cholera Toxin Analysis to Vaccine Design

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8 1 Vibrio cholerae Serogroups

8 2 Cholera Vaccine Candidates

8 3 Cholera Toxin CT

8 5 CT Mutations in Serogroups

Chapter 9 HIV 1 GP160 GP120GP40 Trimer ENV Spike Protein

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9 1 HIV 1AIDS Vaccine Trials

9 2 HIV 1 GP160 GP120GP40 Trimer ENV Spike Protein Complex

9 3 Glycosylation of HIV 1 ENV Spike Protein Complex The HIV 1 ENV GP160 GP120GP40 trimer spike

9 4 Expression, Purification, and Characterization of ENV Trimer

Chapter 10 Eukaryotic Genes, Functions, Genomes, Design, and Evolution

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10 1 Eukaryotic Genes and Genomes

10 3 Genome SEGE

10 4 Human Single Exon Genes

10.7 Alterative Splicing

10 8 Intron and Exon Content in Genomes

10 9 Exon Intron Length Patterns

10 10 Intron Organization and Evolution

10 11 Conclusion

Bioinformation Discovery: Data to Knowledge in Biology | Book Club |

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